Use of Solid Basic Catalysts in the Preparation of Cyclohexenone Derivatives and Evaluation of Their Bacterial Activity
Keywords:
Heterocyclic, catalyst, Cyclohexenone, biological activityAbstract
Solid basic catalysts prepared from the reaction of potassium nitrate with alumina were used to synthesize hexagonal rings derived from cyclohexene by reacting the prepared chalcones with ethyl acetoacetate. Using the catalysts as a catalyst, cyclohexene derivatives were prepared. Biological activity was evaluated using two types of bacterial isolates known for their resistance to antibiotics, Gram-negative (Gram -ve) and Gram-positive (Gram +ve). In addition to determining the melting point and purity, physical and spectroscopic methods such as infrared spectroscopy, proton spectroscopy and carbon nuclear magnetic resonance (1H, 13C-NMR) were used to confirm the correct structure of the prepared compounds, and follow-up analysis was carried out by thin layer chromatography (TLC).
References
Abdullah, S. H., Salih, M. M., & Khalid, A. Synthesis, Characterization and Antibacterial Evaluation of Novel Thiazolidine Derivatives.
Abdullah, S. H., Salih, M. M., & Khalid, A. Al-Badrany.(2024). Synthesis, characterization and Antibacterial Evaluation of Novel Thiazolidine Derivatives. Journal of Angiotherapy, 8(3), 1-6.
Abdullah, S. H., Salih, M. M., & Khalid, A. Synthesis, Characterization and Antibacterial Evaluation of Novel Thiazolidine Derivatives.
Abdul Wahed, A. S. T. (2024). Preparation and Evaluation of Bacterial Activity and Study of the Crystalline Properties of Some 1, 3-Oxazepine-4, 7-Dione Derivatives. Central Asian Journal of Theoretical and Applied Sciences, 5(2), 15-26.
Al-Tufah, M. M., Jasim, S. S., & Al-Badrany, K. A. (2020). Synthesis and Antibacterial Evaluation of some New Pyrazole Derivatives. Prof.(Dr) RK Sharma, 20(3), 178.
Al Rashidy, A. A. M., Al Badrany, K. A., & Al Garagoly, G. M. (2020, August). Spectrophotometric determination of sulphamethoxazole drug by new pyrazoline derived from 2, 4-dinitro phenyl hydrazine. In Materials Science Forum (Vol. 1002, pp. 350-359). Trans Tech Publications Ltd.
Al-Joboury, N. A., Al-Badrany, K. A., Hamed, A. S., & Aljoboury, W. M. (2019). SYNTHESIS OF SOME NEW THIAZEPINE COMPOUNDS DERIVED FROM CHALCONES AND EVALUATION THERE BIOCHEMICAL AND BIOLOGICAL ACTIVITY. Biochemical & Cellular Archives, 19(2).
Aftan, M. M., Salih, H. K., & Talloh, A. A. (2021). Synthesis of new mesogenic Schiff bases ether with polar halogen Substituent and study their liquid crystalline properties. Journal of Education and Scientific Studies, 5(17).
Aftan, M. M., Talloh, A. A., Dalaf, A. H., & Salih, H. K. (2021). Impact para position on rho value and rate constant and study of liquid crystalline behavior of azo compounds. Materials Today: Proceedings, 45, 5529-5534.
Asmaa Ahmed Mohammed Alrashidy, Omar Adnan Hashem, Kalid Abdul-Aziz ALBadrany. (2024). Spectrophotometric Determination of Vitamin C Using Indirect Oxidation with a New Organic Dye, Journal of Angiotherpay, 8(2), 1-7, 9499
Al-Badrany, K. A., Hamad, A. S., & Al-Juboori, I. K. (2013). Synthesis of Some Mannich and 2, 5-Disubstituted 4-Thiazolidinone Compounds Derived from 4-amino Sulphamethaoxazole. Kirkuk Journal of Science, 8(3).
Al-Badrany, K. A., Jasim, S. S., & Al-Tufah, M. M. (2020). Synthesis of some of the compounds of Chalcones and pyrozoline containing phthalimide unit and evaluation their biological activity of some of them. Samarra Journal of Pure and Applied Science, 2(4).]
Al-Sabawy, S. M. I. (2024). SYNTHESIS AND CHARACTERIZATION AND BIOLOGICAL STUDY OF SOME CYCLOHEXENONE DERIVATAVES FROM 2-ACETYL PYROL. EUROPEAN JOURNAL OF MODERN MEDICINE AND PRACTICE, 4(7), 321-329.
Al-Tufah, M. M., Jasim, S. S., & Al-Badrany, K. A. (2020). Synthesis and Antibacterial Evaluation of some New Pyrazole Derivatives. Prof.(Dr) RK Sharma, 20(3), 178.
Al-Joboury, I. K., & Al-Badrany, K. A. Synthesis of some new 3-chloro-4-aryl-2-azitidinone.
Al-jobury, I., S Mohammed, A., & A Al-badrany, K. (2016). Synthesis of some new Pyrazoline derivatives derived from Ibuprofen. Kirkuk Journal of Science, 11(3), 254-262.
Al-Joboury, W. M., Al-Badrany, K. A., & Asli, N. J. (2022, November). N-alkylation of substituted 2-amino benzothiazoles by 1, 4-bis (bromo methyl) benzene on mixed oxides at room temperature and study their biological activity. In AIP Conference Proceedings (Vol. 2394, No. 1). AIP Publishing.
Al-Joboury, W. M., Al-Badrany, K. A., & Asli, N. J. (2021). Synthesis of new azo dye compounds derived from 2-aminobenzothiazole and study their biological activity. Materials Today: Proceedings, 47, 5977-5982.
Chen, J. X., Xia, D. D., Yang, X. Q., Yang, Y. B., & Ding, Z. T. (2022). The antifeedant and antifungal cryptic metabolites isolated from tobacco endophytes induced by host medium and coculture. Fitoterapia, 163, 105335.
Dalaf, A. H., Saleh, M. J., & Saleh, J. N. (2024). GREEN SYNTHESIS, CHARACTERIZATION, AND MULTIFACETED EVALUATION OF THIAZOLIDINONE DERIVATIVES: A STUDY ON BIOLOGICAL AND LASER EFFICACY. European Journal of Modern Medicine and Practice, 4(7), 155-168.
Džambić, A., Muratović, S., Veljović, E., Softić, A., Dautović, E., & Šljivić, M. (2020). Evaluation of antioxidative, antimicrobial and cytotoxic activity of the synthetized arylmethylenbis (3-hydroxy-5, 5-dimethyl-2-cyclohexen-1-one) derivatives. Eur Chem Bull, 9(9), 285-290.
Farah M. Muhammad, Bushra A. Khairallah, K. A. Albadrany. (2024). Synthesis, characterization and Antibacterial Evaluation of Novel 1,3-Oxazepine Derivatives Using A Cycloaddition Approach, Journal of Angiotherapy, 8(3), 1-9, 9506
Jasim, S. S., Al-tufah, M. M., & Al-badrany, K. A. (2021). Synthesis and antibacterial evaluation of some New 1,
Mohammed Jwher Saleh, Jamil Nadhem Saleh, Khalid Al-Badrany, Adil Hussein Dalaf, Reem Suhail Najm, & Abdul Wahed Abdul Sattar Talluh. (2024). Preparation And Evaluation Of The Biological Activity Of A 2- Amino Pyran Ring Using A Solid Base Catalyst. Central Asian Journal of Medical and Natural Science, 5(4), 130 - 138.
Muhammad, F. M., Khairallah, B. A., Saleh, M. J., & Saleh, J. N. (2024). Preparation and Characterization of New Rings of Oxazine Derivatives and Studying Their Biological and Laser Effectiveness and Molecular Docking. Central Asian Journal of Theoretical and Applied Science, 5(4), 190-201.
Muhammed al-jubure, E. J., & Al-Badrany, K. (2024). Synthesis and Characterization and Biological Study of Some Oxazepine Derivatives from 2-Acetylthiazole. World of Medicine: Journal of Biomedical Sciences, 1(8), 40-48.
Mohamed, S. A., Hussein, M. S., & Al-badrany, K. A. (2022). Synthesis and characterization of pyrazolines and oxazapine derivatives using chalcones as precursor and evaluation of their biological activity. Samarra Journal of Pure and Applied Science, 4(4).
Mohamed, S. A., Al-Badrany, K. A., & Huseen, M. S. (2022). Preparation and Study of Biological Activity of Pyrimidine Compounds Derived from 2-Acetylpyridine. Vegueta. Anuario de la Facultad de Geografía e Historia, 22(8).
Najm, R. S., Shannak, Q. A., & Dalaf, A. H. (2023). Synthesis and Decoration of Aromatic Derivatives Nano Platelets by the Electric Method. Azerbaijan Pharmaceutical and Pharmacotherapy Journal, 22(2), 92-97.
Najm, R. S., & Al-Somaidaie, G. H. (2022, August). Carbonation and Preparation of Reduced Graphene Oxide Sheets from Cellulose. In 39th PATTAYA International Conference on “Advances in Chemical, Agriculture, Biology & Environment”(PCABE-22) Pattaya (Thailand) Aug (pp. 25-26).
NAJM, R. S. (2019). Synthesis and biological activity evaluation of some new pyrazole derivatives. International Journal of Pharmaceutical Research, 11(1).
Najm, R. S. (2020). SYNTHESIS AND BIOLOGICAL ACTIVITY EVALUATION OF SOME NEW 1, 3, 5 TRIAZINE DERIVATIVES FROM-2-CARBOXYLIC ACID. Biochemical & Cellular Archives, 20(2).
Owed, A. I., Al-Jubouri, A. A., & Al-Samarrai, S. Y. (2024). A nano-sensor for copper oxide was manufactured and developed using a new organic precipitant via green chemistry methods. Sensors and Machine Learning Applications, 1(1).
Riester, O., Burkhardtsmaier, P., Gurung, Y., Laufer, S., Deigner, H. P., & Schmidt, M. S. (2022). Synergy of R-(–) carvone and cyclohexenone-based carbasugar precursors with antibiotics to enhance antibiotic potency and inhibit biofilm formation. Scientific Reports, 12(1), 18019.
Qu, C. H., Song, G. T., Huang, J. H., Huang, R., Chen, Y., Liu, T., ... & Chen, Z. Z. (2021). Tandem isonitrile insertion/azacyclopropylidene-annulated cyclohexenone–tropone rearrangement of p-QMs and TosMIC: de novo synthesis of pyrrolotropones with anti-cancer activity. Organic Chemistry Frontiers, 8(23), 6515-6521.
Salih, B. D., Mohammed, A. S., Najm, R. S., Mahmood, A. R., & Alheety, M. A. (2024). Ortho‐and Para‐Nitrile Substituted Effect of (1H‐Indol‐2‐Yl) Benzonitrile‐Boehmite on the Nano Structures, Surface Area and Hydrogen Storage. Energy Storage, 6(6), e70034.
Shannak, Q. A., Najim, T. M., & Madab, D. I. (2022). Evaluation of the level of vitamin D3 in the blood serum of patients infected with COVID-19 in Al-Amiriya city. Technium BioChemMed, 3(2), 127-135.
Shannak, M. Q. A., Othman, I. A. W., Rasheed, M. K., & Mahmood, S. K. (2018). Synthesis and Characterization of New Some Binuclear Complexes for Some Transition Element Metals with Schiff Base ligand Derived from 1-Chloro-2-(2-Chloroethoxy) Ethane. Eurasian Journal of Analytical Chemistry, 13, 339-346.
Shannak, Q. A., Madab, D. I., & Mohammed, S. (2021). “PhD. Organic Chemistry, Ministry of Education, Salah Al-Din. Annals of RSCB, 25(6), 5432-5441.
Shannak, Q. A. (2020). Characteristic Studying and Biological Effect of Synthesized Complexes Pd (II) and Hg (II) with Uracil dithiocarbamate and Phosphine’s. Systematic Reviews in Pharmacy, 11(3), 693-701.
Saleh, M. J., Saleh, J. N., & Al-Badrany, K. (2024). PREPARATION, CHARACTERIZATION, AND EVALUATION OF THE BIOLOGICAL ACTIVITY OF PYRAZOLINE DERIVATIVES PREPARED USING A SOLID BASE CATALYST. EUROPEAN JOURNAL OF MODERN MEDICINE AND PRACTICE, 4(7), 25-32.
Saleh, M. J., & Al-Badrany, K. A. (2023). Preparation, characterization of new 2-oxo pyran derivatives by AL2O3-OK solid base catalyst and biological activity evaluation. Central Asian Journal of Medical and Natural Science, 4(4), 222-230.
Saleh, M. M. Amenah l. Al-Nassiry, Jamil Nadhem Saleh, & Mohammed Jwher Saleh.(2024). Preparation and Diagnosis of New Complexes for Hg (II) With 4-Amino Acetanilide And (Dppp) As A Ligand And Study Of The Bacterial Efficacy And Molecular Docking Of The Prepared Complexes. Central Asian Journal of Theoretical and Applied Science, 5(4), 364-373.
Saleh, J. N., & Khalid, A. (2023). Synthesis, characterization and biological activity evaluation of some new pyrimidine derivatives by solid base catalyst AL2O3-OBa. Central Asian Journal of Medical and Natural Science, 4(4), 231-239.
Saleh, R. H., Rashid, W. M., Dalaf, A. H., Al-Badrany, K. A., & Mohammed, O. A. (2020). Synthesis of some new
Sattar Talluh, A. W. A., Saleh, J. N., Saleh, M. J., & Saleh Al-Jubori, H. M. (2024). Preparation and Characterization of New Imidazole Derivatives Derived From Hydrazones and Study of their Biological and Laser Efficacy. Central Asian Journal of Theoretical and Applied Science, 5(4), 202-211.
Saleh, M. M., Saleh, J. N., Rokan, F. F., & Saleh, M. J. (2024). Synthesis, Charactarizit and evaluation of bacterial efficacy and study of molecular substrates of cobalt (II) complex [Co (2-(benzo [d] thiazol-2-yloxy) acetohydrazide)(H2O)(Cl2)]. Central Asian Journal of Medical and Natural Science, 5(4).
Talluh, A. W. A. S., Saleh, M. J., Saleh, J. N., & Al-Jubori, H. M. S. (2024). Synthesis and Characterization of Some New Imine Graphene Derivatives and Evaluation of Their Biological Activity. Central Asian Journal of Medical and Natural Science, 5(4), 272-290.
Talluh, A. W. A. S., Najm, R. S., Saleh, M. J., & Saleh, J. N. (2024). Synthesis, Characterization, and Evaluation of the Biological Activity of Novel Oxazepine Compounds Derived From Indole-5-Carboxylic Acid. American Journal of Bioscience and Clinical Integrity, 1(8), 10-19.
Talluh, A. W. A. S., Saleh, J. N., & Saleh, M. J. (2024). Preparation, Characterization and Evaluation of Biological Activity and Study of Molecular Docking of Some New Thiazoli-dine Derivatives.
Talluh, A. W. A. S., Saleh, M. J., Saleh, J. N., Al-Badrany, K., & mohammed saleh Al-Jubori, H. (2024). Preparation, characterization, and evaluation of the biological activity of new 2, 3-dihydroquinazoline-4-one derivatives. EUROPEAN JOURNAL OF MODERN MEDICINE AND PRACTICE, 4(4), 326-332.
Talluh, A. W. A. S. (2024). Preparation, Characterization, Evaluation of Biological Activity, and Study of Molecular Docking of Azetidine Derivatives. Central Asian Journal of Medical and Natural Science, 5(1), 608-616.
Talluh, A. W. A. S., Saleh, M. J., & Saleh, J. N. (2024). Preparation, Characterisation and Study of the Molecular Docking of Some Derivatives of the Tetrazole Ring and Evaluation of their Biological Activity. World of Medicine: Journal of Biomedical Sciences, 1(7), 15-23.
Thalij, K. M., Al-badrany, K. A., & Al-Juboury, I. K. (2015). Synthesis of Some New Derivatives of 2-hydrazeno-benzo-thiazole 2-mercpto-benzothiazole and Used as Fungicide Agents. Asian Journal of Applied Sciences, 3(3).
thiazolidinone compounds derived from schiff bases compounds and evaluation of their laser and biological efficacy. Ann Trop & Public Health, 23(7), 1012-1031.
Wadee, S. A., Majeed, H. M., & Najm, R. S. (2021). Evaluations Of Antibacterial Efficiency of Nife2o4 Nanoparticles Alone and in Combination With Some Antibiotics Against Multidrug Resistant Proteus Mirabilis. January 2022.
5-Benzooxazepines derivatives. Syst Rev Pharm, 12(3), 270-285.
